Red devil trial

Why did this happen? One possibility is dosage. The dose in the combination was 2. In the basket trial, it was 3. In evaluating this possibility, the companies put out a poster [at the International Association for the Study of Lung Cancer World Conference on Lung Cancer] that looked at the relationship between AUC [area under the curve] dose exposure and both response rate and toxicity.

It showed that when the exposure was ideal, the response rate was quite a bit better and the toxicity more limited. That argues that the dose really might have mattered. Unfortunately, the AUC exposure was fairly broad at that 3. Still, it does make common sense that if the patients are at 3. Where does that leave us? Thank you so much for this and yes, you are all not alone — despite it often feeling that way x and yes always ask away x. I finished my red devil treatment which I had once a fortnight my first and last were my worst.

I have my fourth dose tomorrow of the second round. All you can do is take one day at a time They told me the second round of chemo is smoother and for me it is.

But still not fun. I wish you all the best keep positive attitude it feels better to laugh. Thank you so much Hayley and the best of love and luck to you too!

And yes, I found taxol much easier than red devil. Thankfully, I just finished my 4th and final treatment of Red Devil. I did the cold cap. I have probably 46 hairs left, but I kept my fringe bangs. So maybe I would have kept hairs, my hope is when they are done dosing me with chemicals it will grow back the same and maybe faster. Did lose a ton of my eye lashes. Luckily I feel OK most of the times. I avoid taking any anti-nausea pills. They make me feel crappy.

I stopped after the first chemo. Hot heated hate. It gets in the way when I lift stuff, sleep, swing my golf club and finally the seat belt. It looks like a bruised lump in my chest plus it hurts when touched or they hang the IV. I have been hospitalized cause I had no white blood cells, but I felt fine. They worry because I got a bit of anemia going on. I have the triple neg breast cancer and I am Luckily, I am still working. That helps. I do get way more tired at the end of the day, but that is probably the anemia, which is kinda new.

I start the ever-green chemo next Thursday. Kinda anxious because it is a change. But no Neulasta. After the shot even taking the Claritin I felt weird. Not right. I do have to worry about Diarrhea issues. I have developed something of a spastic colon. So 12 freaking weeks of the Taxol. Then under the knife. Who knows. Just keep moving forward. What tears me up are all the younger women.

Hurray to finishing!! Ha yes, it was awesome to not have to shave everything : Wishing you the absolute BEST of luck Jessica with the rest of your chemo and surgery — love to you x x. Thanks for sharing. I found your blog looking for information on these Red Devil chemo treatments. Your story has educated me and made me realize all the things I have been blessed with and am so thankful for.

My reason for searching is re-connecting with a good friend who has 2 young children; and he also has stage 2 lymphoma. He said they gave him 6 of these AC treatments and he continued to work every day while receiving them, and 6 days a week the past year since having them. He just found out last week that the cancer is back last week is also when we ran back in to each other after not seeing each other in over 10 years.

They are going to begin treatments on him again in about 5 days. I am determined not to let him go through this alone this time and to do as much for him to make this easier or more comfortable, without getting in his personal space, so I wanted to really do some crash studying up on what to expect. To know what he was going to be going through. Reading your blog has been the most helpful thing I have come across yet, by far.

You are truly a strong willed lady, and a beautiful person. There should be many more like you in the world. Thank you for sharing your experience. You have helped so many people by doing so.

I wish you much luck and many days! Hi Lana! I have everything crossed for him that treatment will be a huge success x x x. I stumbled across you blog in a search for info. I have just finished round 4 of AC. It was like looking in the mirror. I hope your AC 3 and 4 are kinder to you than me.

But I made it. And now getting ready for Taxol. Thankyou for sharing. I am about to make my partner read it as he will be blown away that the struggle is not unique to me. Hi Jenny! Thank you for sharing your story. Thanks gain for sharing. Thank you for enlightening us with your experience. A dear friend is going through her second round and it breaks my heart. But she is strong and am thankful for the information here because I want to be aware of what she is going through and be there for her the best way I can.

Lots of love to you and your friend — it can be such a hard time. Not everyone experiences it the same way and some are very lucky with few symptoms. I can tell you now that 6 months after chemo finished, I feel like a different person and so so much better. Hi Mim, Found your Blog while looking for info on side effects for 2nd treatment of Chemo, was a bit scary to say the least, but you came through at the other end so I suppose I will too. So far worst has been the dry mouth like you have eaten a handful of flour, but that has now passed.

I also ended up with an infected finger from a small scratch, which I required antibiotics for, just so much fun. Thanks for the Blog. I only found your blog last week and I really wish I had found it sooner.

I was diagnosed with breast cancer in November and started the first of 4 AC chemotherapy on the 15th of December. Reading this really upset and touched me, it is like you were me, you wrote everything I felt and I only wish I could have put it into words as honest and eloquent as you did, maybe then the people around me would have had better understanding of how awful AC really is. Your attitude is fantastic and I really enjoy your blog. Email me if you ever want a chat — I hope your treatment is going really well : x.

I hope round three is easier on you. Mim, my love you ARE amazing. Thank you for sharing, for your honesty and for your courage. I had absolutely no idea how truly horrific chemo is. I appreciate your brutal honesty. I am praying that round three is going better than rounds 1 and 2. I am hugging my babies a little tighter today. I hope that your third treatment went as well as it can do.

Lots of love xx. I had my 3rd round this Monday and I already feel so much stronger in dealing with it — hoping that continues! This is incredible. Your honesty is breathtaking. Thank you so much for sharing this experience and I wish you so much luck for the rest of your treatment xxx.

Your honesty and pain brought me to tears. Thank you for sharing your brutal and honest account of your treatment. Love you lady — thanks so much for linking up with TwinklyTuesday. What a beautifully written post Mim. I think that you are wonderfully inspiring and probably the bravest woman I know. Sending so much love to you.

Thank you so much lovely! Bless you Mim… Wish I was there in person to give you the biggest hug xx You have been very much in my thoughts along with my Auntie. A very honest account of what you are going through. Which is not necessarily the case. Sat with tears in my eyes.. You can do this Mim! Oh Mim, so accurate, so shit and yet so beautifully written. Sending so much love and strength to Oz.

PS I bet you make a beautiful George Dawes???? When I read a post like this it really does put life in perspective, I truly hope that you beat this. You sound like an incredibly brave lady and I think you are right to share the harshness of the treatment you are enduring. Mim, I am sitting here with tears rolling down my face. You are such a brave, inspiring, wonderful woman.

You really are amazing. Oh thank you Fern! I hope you never have to — I wish no-one would ever have to do this. Thinking of my little family gets me through more than anything else x x. Mim, thank you for writing so honestly about your experiences of this illness and the treatment that goes with it. I feel as though I have learned a lot and take away from it new found knowledge that helps me in understanding more about how my own friends and family who have been affected by this bastarding thing.

Enjoy these next days with your family in the sunshine, and the biggest of well wishes for the next lot of treatment. Oh Mim. Sending all the love and strength I possibly can xxxx. You are inspirational and I am in awe. Sending all my love and best wishes to you xx. I feel so ignorant having read this. I knew it was awful but I had no idea about using a separate toilet and the potential for early menopause and fingernails falling off.

Thank you for writing this account. Remember mine is AC chemo and your friend might have been on a completely different and hopefully not as harsh chemo.

I wish you all the best with the treatment, fingers crossed the second set is not as bad. Oh thank you Claire x x please know I am feeling MUCH better since writing the post, it was very therapeutic and the worst of my side effects have definitely gone for this cycle : Bring on the next one!

Thank you so much Robyn, I would love to be able to help others understand more for if they or their family have to go through it. Oh Mim, I read your post and I could hear the pain in your words, the sadness and the anger.

You have been through so much and it isnt even over yet, but survived. You are so strong and so brave. I had no idea just how awful and exhausting chemo is.

Thank you for opening my eyes. I hope that knowing some of us out here are following your story and care x. Emily TwinklyTuesday. You are one brave lady and you are and will fight this! Thank you for sharing your journey.

Sending you loads of love twinklytuesday xx. Honestly you are so freaking brave!!! Your insight will no doubt be very helpful for those that are going through it! I am glad you have written this. I used to work in oncology and you have no flipping clue how people are feeling. Dear sweet Mim, there are no words but know we are all rooting for you. Wishing you an easier experience third time around. Much love and lots of hugs xxx.

Bloody hell I just want to give you a huge hug. I think you have absolutely done the right thing sharing the full story here as if it were me searching google for answers I would want to know. Lots of love to you and a big hug for your husband too, sounds like he is a marvel.

This is such a brilliantly written post. I feel your anger, but also your pain at going through this bloody awful thing. Also, deb sounds amazing! This path might be awful, but there are some bloody good people along the way too. I want to hug you. What can I say other than you are amazing.

You are an absolutely incredible human and thank you for sharing this. I am so in awe of your bravery and your strength. Sending you so much love, light and many more big hugs. Oh Mim — it is such an horrendous time and I know exactly how you are feeling. One of the best things in my life was ticking off each session and counting down to the last. Like you, I quickly learned who my true friends were.

If you can, try and eat small amounts even like a ginger biscuit often. Ginger can help with nausea sometimes although I know how metallic and disgusting everything tastes. On week 3 try and get as much fresh air as you can as I think this really helps. Well done for being so brave about your hair!

Sending lots of love and good luck for your next treatment, Mim. Thank you thank you Sara, I know how you understand x x I love ticking off the sessions too — it feels like such a long way off but I cannot wait to get to the last one and give it a big TICK! Hang in there Mim. Kym and I were moved by your account and admire your courage. We are so sorry that you have to endure such horrible treatment, but you are on the downhill run now. Sending you all our love and best wishes.

Reading this I really wanted to comment. You have really done the right thing in sharing your treatment. It sounds really hard what you are going through but not because of the way you have written it but because that is the way it is and I think it is great that you have documented it. You are really strong and brave lady and I think that your honest account will not only help you, because it is so empowering but others too Thank you for sharing xx Ps Debs does sound amazing and lovely!

I think you did the right thing sharing everything like in this post. I had no idea what it entailed fully for you physically and mentally. I hope that your next round of chemo are a little easier on you. This made me cry. Tears for everyone going through this and awe for the strength and courage you all have. Everything I want to say to you feels like a cliche, or feels empty because I have not walked in your shoes so cannot truly understand. My thoughts are with you Mim. I think you are an incredible and strong woman and you are going to kick its ass.

Hoping the next two go easier on you. Keep going x. I am really not sure what to say here. Your increadable. Your increadable not only for being able to face that, but for being able to put it into words that tell us the honest truth of chemo without making it sound like a horror story or a pity party.

I can only hope that your next two sessions will be no worse than that, and that it does manage to kick the cancers arse. Your email address will not be published. This site uses Akismet to reduce spam. Learn how your comment data is processed. Best Planners for Mums. Privacy Policy.